What is it?
In the United States, Tixocortol-21- pivalate is a type of cortisone used as a screening agent to detect other topical steroid sensitivities.  

How do I avoid it?
There are many types of cortisone products. An allergy to Tixocortol-21-Pivalate does not mean you are allergic to all cortisones.

Skin contact with  Tixocortol-21- pivalate is required for it to cause a rash. Discontinuation of exposure to products containing Tixocortol-21- pivalate should result in improvement and/or resolution of your dermatitis. The most common cause of allergic contact dermatitis from Tixocortol-21- pivalate is corticosteroid creams. By law, all products made in the US for topical use have the ingredients listed either on the product package or the box that contains it, so check the labeling of your person care products and topical medication.   If there is no information ask your pharmacist.  At work, request a material safety data sheet (MSDS) to help identify potential sources of exposure.

Hydrocortisone & Hydrocortisone acetate is available without prescription so the ingredient list of any medicated cream, lotion, or the like should be read before purchasing, to be certain that it does not contain either agent.

You should alert your health care provider of this allergy. Your physician may wish to further study this allergy by testing to several corticosteroids so that you may use safer corticosteroids if necessary in the future.

  • Anti-inflammatory agents
  • Ear, eye nose drops and sprays
  • Enemas
  • Inhalers for allergy or asthma
  • Over-the-counter itch and rash remedies
  • Prescription creams, lotions, solutions, gels, powders and ointments
  • Medicated tapes used for eczema

Other names for Tixocortol-21- pivalate:
  • (11b)-21-[(2,2-dimethyl-1-oxo-propyl)thio]-11,17-dihydroxypregn-4-ene-3,20-dione
  • JO 1016
  • Pivalone
  • Procolon
  • Rectovalone
  • Tivalon-NT
  • Tiprederm
  • Tixocortol pivalate

Potential cross-reacting/co-reacting substances:
In most patients, cross-reaction is only for cortisones used topically. This test does not predict, nor make any statement about cortisone taken internally (oral or injection).
  • Cloprednol
  • Cortisone acetate
  • Dichlorisone acetate
  • Difluprednate
  • Fludrocortisone acetate
  • Fluorometholone
  • Fluprednisolone acetate
  • Hydrocortisone
  • Hydrocortisone aceponatc
  • Hydrocortisone acetate
  • Hydrocortisone-17-butyrate
  • Hydrocortisone-21-butyratc
  • Hydrocortisone hemisuccinate
  • Isofluprednone acetate
  • Mazipredone
  • Medrysone
  • Methylprednisolone aceponate
  • Methylprednisolone acetate
  • Methylprednisolone hemisuccinate
  • Prednicarbate
  • Prednisolone
  • Prednisolone caproate
  • Prednisolone pivalate
  • Prednisolone sodium
  • metasulphobcnzoate
  • Prednisolone succinate
  • Prednisone
  • Tixocortol pivalate
  • Triamcinolone

How safe is it?

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