What is it?
PPD is the compound responsible for coloring in permanent hair dyes.

How can I avoid it?
PPD is a chemical found in permanent hair dyes in the United States and the United Kingdom. Most cases of PPD sensitivity arise from the use of permanent hair dyes. PPD needs a second compound, like a developer or oxidizer to produce a dark color. It is important to note that fully developed or oxidized PPD dye is not an allergen. This means that hair or fur that has already been dyed is safe to touch.

For persons who want to continue dying their hair, semi-permanent (not containing PPD) or temporary hair dyes may be a good alternative. Patients allergic to PPD may be able to tolerate hair dyes where the active hair colorant is Methoxymethyl-phenylenediamine.

For a hairdresser or those with continuous exposure to PPD, it is best to avoid dying clients’ hair. Wearing latex, nitrile, or 4-H gloves is helpful but can interfere with manual dexterity. If necessary, it is recommended to double glove to prevent small molecules of PPD from penetrating the gloves and contacting the skin.

Other names for p-Phenylenediamine:
  • 1,4-Benzonediamine
  • 1,4-Diaminobenzene
  • 1,4-Phenylenediamine
  • 4-aminoaniline
  • 4-Phenylenediamine
  • Orsin
  • p-Aminoaniline
  • p-Aminoanitral
  • para-phenylenediamine
  • p-Diaminobenzene
  • Rodol D
  • Ursol D

Potential cross-reacting/co-reacting substances:
  • Other para-amino compounds
  • Dyes
    • Disperse dyes
    • p-toluenediamine
    • Food dyes (citrus red 2, sunset yellow)
  • Para-Aminobenzoic acid (PABA, a sunscreen ingredient)
  • Medications, specifically sulfa drugs
    • Sulfa antibiotics such as sulfanilamide
    • Sulfonylurea diabetic medications
    • Procaine anesthetics
  • p-Aminophenol (PAP)
  • p-Aminoazobenzene (PAAB)
  • 4,4’-Diaminodiphenylmethane (DDM)

MCS7562-265rev1121

How safe is it?

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