What is it? 
Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde (Lyral) is a fragrance used in a variety of products such as personal care products and perfumes.

How can I avoid it? 
Avoidance requires reading the product labels, package inserts, Safety Data Sheets (SDS), and on occasion, direct communication with the manufacturer.

The avoidance of fragrances such as Hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral) can be difficult, since so many everyday products contain these substances. One should use only fragrance-free cosmetic and household products. “Unscented” products may contain low levels of a fragrance to cover up an undesirable odor and also should be avoided. Products labeled as “hypoallergenic” do not assure that the product is truly free of fragrance.

Since fragrances are complex mixtures of many ingredients, an individual may tolerate one fragrance but not another. A trial-and-error method of avoiding a fragrance allergen in a product can be performed by applying the product to the forearm in the same small area twice a day for a week. If no dermatitis develops, the product may likely be used safely.

Since some fragrances are also flavors, foods can, rarely, cause flare-ups of dermatitis in fragrance-sensitive individuals. Particularly if you have oral or lip allergies as discussed with your health care provider, you should avoid foods prepared with Hydroxyisohexyl 3-cyclohexene carboxaldehyde (Hydroxyisohexyl 3-cyclohexene carboxaldehyde [Lyral]).

Skin contact with Hydroxyisohexyl 3-cyclohexene carboxaldehyde (Hydroxyisohexyl 3-cyclohexene carboxaldehyde [Lyral]) is required for it to cause a rash. Discontinuation of exposure to products containing Hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral) should result in improvement and/or resolution of your dermatitis. By law, all products made in the U.S. for topical use have
the ingredients listed either on the product package or the box that contains it, so check the labeling of your skin care products for this ingredient. If there is no information ask your pharmacist or call the company directly. At work, request a Safety Data Sheet (SDS) to help identify potential sources of exposure.

  • Perfumes / Colognes / After-shaves / Toilet water
  • Skin Care Products / Cosmetics 
    • Antiperspirants / Deodorants 
    • Hair sprays, gels, tonics and lotions 
    • Make-ups 
    • Moisturizers 
    • Powders / Sprays 
    • Shampoos / Conditioners 
    • Shaving products 
    • Soaps / Cleansers 
    • Sunscreens and Self-Tanners
  • Medications, topical, prescription and over the counter such as 
    • Anesthetics 
    • Antiseptics 
    • Creams, Ointments, Solutions 
    • Foot And Other Powders 
    • Nasal Decongestants 
    • Herbal remedies, including Traditional Chinese Medications
    • Wound Dressings
  • Household products 
    • Air Fresheners / Aromatherapy / Potpourri
    • Cleaning Products / Soaps / Detergents (A preferred household cleaner is dilute white vinegar.) 
    • Furniture polish 
    • Laundry care (detergent, softeners)
Other names for Lyral: 
  • Hydroxy-4-methyl-pentyl-3-cyclohexen-1-carboxaldehyde 3 and 4-(4- 
  • Hydroxy 3-cyclohexene carboxaldehyde 
  • HM PCC 
  • HICC
  • Hydroxymethylpentylcyclohexenecarboxaldehyde
  • Kovanol
  • Mugonal
Potential cross-reacting/co-reacting substances: 
  • Fragrances 

How safe is it?

Hang tight. We're thinking.